Betting

Chargers vs. Cardinals prediction: NFL odds, picks, best bets for ‘MNF’

Game 2 of Monday night’s NFL doubleheader features an inter-conference matchup between the Chargers and Cardinals — teams searching for consistency and upward movement in the standings.

Here’s a preview 𝓀of the matchup with a pick on the spread and the over/under.

Chargers vs. Cardinals odds

TeamSpreadMoneylineOver/Under
Chargers-2 (-110)-190o49 (-110)
Cardinals+2 (-110)+160u49 (-110)
Odds via bet365

Chargers vs. Cardinals spread

The spread opened with the Cardinals as one-point road favorites but has since flipped toward the Chargers. L.A. has a 3-2 record against the spread, while Arizona ꦚsits at 3-3.

Even though the Cardinals logged an impressive road win against San Francisco, an upset on Monday night doesn’t seem to be 🐎in the cards.

Los Angeles has a stifling defense that ranks thir😼d in defensive EPA/play and defensive DVOA, sixth in opponent yards per game and first in opponent points per gඣame.

Meanwhile, Arizona’s defense hasn’t been much better than last season, receiving the third-lowest grade for overall defense by Pro Football Focus and ranking 31st in opponent rushing yards per game (182.7) over the last three weeks.

The run-heavy Chargers understand their stren🎃gths and weaknesses on offense, as the passing game h💃as been suspect, but its running backs have been terrific on the ground and the O-line has dominated the trenches.

Don’t expect Los Angeles to bail Arizona out with a ton of pas𝓰s plays; the Chargers will pound the ball until the Cardinals’ def𓄧ense breaks. 

Pick: Chargers -1.5 (-108, Fanatics)

Kyler Murray could have problems against the Chargers' top-ranked defense on Monday night.
Kyler Murray could have problems against the Chargers’ top-ranked defense on Monday night. Getty Images

Chargers vs. Cardinals point total

The Chargers have only gone over the tot⛄al in one of their five games, while the Cardinals have an over record of 3-2-1.

Los Angeles’ defense has been sensational under Jim Harbaugh, holding opponents to just 13.2 points per game, the lowest number in the NFL. The Charg⛦ers have held all five of their opponents this season to 20 points or fewer.


Betting on the NFL?


None of their games have come close to this 44.5-point line, and we don’t see Arizona’s offense having much success against the Chargers’ top-ranked defense.

The Cardinals have scored 14 or fewer point♔s in three of their last four games, with the only exceptio🐷n being the shocking road win against the Niners.

Pick: Under 44 points (-108, ESPN BET)


Why Trust New York Post Betting

Andrew Norton handicaps the NBA, WNBA, NFL, college basketball and football, UFC and golf. During the 🍃2022-23 NBA season, he achieved a standout 14.1% ROI, cashing 60% of his NBA༺ spread picks and leading Tallysight in its SportsIQ metric.